Cognitive Stack

Name: Cognitive Stack
Brand: G Peptide Labs
SKU: GP-187
Price: 85 CAD
Availability: InStock

$85.00

Semax 10mg + Selank 10mg — bundled at a saving — save $15 vs buying separately. Research use only; not for human consumption.

Not for human consumption. Supplied strictly for in-vitro laboratory research use.

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View Lab Report

Purity (HPLC)Verified — see contents

FormatBundle (2 vials)

StorageStore each vial per its own product page.

Category: Stacks

Description
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Description

Overview

The Cognitive Stack pairs two of the most widely studied short regulatory peptides in the neuropeptide literature: Semax, a synthetic analogue of the adrenocorticotropic hormone fragment ACTH(4-7), and Selank, a synthetic analogue of the endogenous immunomodulatory tetrapeptide tuftsin. Both are seven-residue peptides that share a C-terminal Pro-Gly-Pro motif engineered to resist enzymatic breakdown, and both are supplied here as lyophilised powder for laboratory research use only. This bundle is intended to support in-vitro and preclinical experimental designs that examine the two molecules in parallel or in combination.

Every Cognitive Stack shipment is prepared under controlled conditions, assayed for identity and purity, and accompanied by a batch-specific third-party Certificate of Analysis (COA). This product is not a drug, dietary supplement, cosmetic, or food, and it is not intended for human or veterinary use.

Research Context

Semax and Selank both emerged from Russian neuropeptide programmes and have accumulated a substantial preclinical literature spanning rodent behavioural models, ex-vivo tissue preparations, and molecular expression studies. Researchers frequently pair the two because they occupy complementary experimental niches: the Semax scaffold is most often investigated in the context of neurotrophic signalling and cognitive-behavioural paradigms in animal models, while the Selank scaffold is commonly studied in anxiolytic-type, stress-adaptation, and neuroprotection paradigms.

In preclinical studies, Semax has been examined for its influence on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and TrkB expression across hippocampal, cortical, and retinal tissue in rats.
In animal models, Selank has been investigated for effects on BDNF content in the hippocampus and prefrontal cortex and for behavioural readouts under stress and withdrawal conditions.
Combined designs allow investigators to compare two structurally related Pro-Gly-Pro-stabilised heptapeptides under identical in-vitro assay conditions.

All descriptions here summarise findings reported in the published experimental literature. They are provided to contextualise laboratory investigation and make no representation about outcomes in humans.

Mechanism of Interest

The two peptides are of interest to researchers for distinct but overlapping reasons. Semax, as an ACTH(4-7) analogue, is studied for its reported modulation of neurotrophin systems; preclinical reports describe changes in BDNF and TrkB signalling elements following administration in rodent tissue. Selank, as a tuftsin analogue, is examined for reported interactions with GABAergic and monoaminergic signalling and for its influence on BDNF expression in animal models. The shared Pro-Gly-Pro tail is a recurring point of mechanistic interest because it is associated in the literature with improved metabolic stability relative to the parent peptides. These are open questions under active preclinical investigation rather than settled conclusions.

Specifications

Format: two separate vials of lyophilised powder (one Semax, one Selank)
Semax: sequence MEHFPGP; molecular formula C37H51N9O10S; molecular weight 813.9 g/mol; CAS 80714-61-0
Selank: sequence TKPRPGP; molecular formula C33H57N11O9; molecular weight 751.9 g/mol; CAS 129954-34-3
Purity: 99%+ by HPLC (see batch COA for the exact figure)
Identity confirmation: mass spectrometry
Presentation: sterile-filtered, lyophilised; sealed vials

Handling / Reconstitution / Storage

Storage (lyophilised): store sealed vials at -20°C, protected from light and moisture, for long-term stability.
Reconstitution: for in-vitro work, bacteriostatic or sterile water is commonly used as a diluent; the volume is selected by the researcher to match the concentration required by the assay. Add the diluent slowly against the vial wall and allow the powder to dissolve without vigorous agitation.
Storage (reconstituted): keep refrigerated at 2-8°C and use within a short working window; avoid repeated freeze-thaw cycles, which can degrade peptide integrity.
Good practice: handle under aseptic conditions, label aliquots with batch and date, and record reconstitution details for reproducibility.

These handling notes are general laboratory guidance for research materials and are not directions for any form of administration.

Quality & Verification

Each batch is analysed by an independent laboratory, and the corresponding COA reports HPLC purity, mass-spectrometry identity confirmation, and net peptide content. G Peptide Labs is a Canadian research-peptide supplier; the Cognitive Stack ships domestically within Canada with batch traceability from vial to certificate. Researchers are encouraged to review the COA on receipt and to confirm that the reported batch number matches the label on each vial before beginning experimental work.

Selected Research

Peer-reviewed references provided for scientific context; they describe laboratory and preclinical findings only.

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J (2006). PMID: 16996037
Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action. Journal of Molecular Neuroscience Shadrina M, Kolomin T, Agapova T, Agniullin Y, Shram S, Slominsky P, Lymborska S, Myasoedov N (2010). PMID: 19662538
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of Experimental Biology and Medicine Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD (2019). PMID: 31625062
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bulletin of Experimental Biology and Medicine Konstantinopolsky MA, Chernyakova IV, Kolik LG (2022). PMID: 36322304

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Frequently asked questions

How are Semax and Selank reconstituted and stored for research use?

Both are supplied as lyophilised powder. Store the sealed vials at -20°C away from light and moisture. For in-vitro work, researchers typically reconstitute with bacteriostatic or sterile water, adding the diluent slowly against the vial wall and choosing a volume that yields the concentration their assay requires. Once reconstituted, keep the solution at 2-8°C, use it within a short working window, and avoid repeated freeze-thaw cycles that can compromise peptide integrity. These are general laboratory handling notes, not administration instructions.

What purity can I expect, and how do I verify the COA?

Each component is assayed to 99%+ purity by HPLC, with identity confirmed by mass spectrometry. Every shipment includes a batch-specific third-party Certificate of Analysis. To verify it, match the batch or lot number printed on each vial to the number on the COA, then review the reported HPLC purity, the mass-spec identity confirmation, and the net peptide content. If any figure or batch number does not match, contact us before starting work.

What exactly does the Certificate of Analysis confirm?

The COA is an independent laboratory record for a specific production batch. It confirms the peptide's identity by mass spectrometry (that the measured mass corresponds to Semax or Selank), reports the chromatographic purity by HPLC, and states the net peptide content. It provides the traceability link between the physical vial and its documented analytical results. It does not make any claim about biological effect or fitness for any use beyond laboratory research.

How do I choose the right size for my research?

Size selection depends on the scale and duration of the planned in-vitro or preclinical program: the number of assay conditions, replicates, and the working concentrations involved. Smaller quantities suit method development, pilot runs, and single-endpoint experiments, while larger quantities suit extended studies or work that requires many aliquots. Because the two peptides are supplied in separate vials, you can scale each component independently to match your experimental design.

Do you ship the Cognitive Stack within Canada?

Yes. G Peptide Labs is a Canadian research-peptide supplier and ships the Cognitive Stack domestically across Canada with full batch traceability from vial to certificate. Materials are dispatched as research chemicals for laboratory use only.

Why are Semax and Selank offered together as a stack?

They are two structurally related seven-residue peptides that share a C-terminal Pro-Gly-Pro stabilising motif but derive from different parent molecules (ACTH(4-7) for Semax, tuftsin for Selank). Pairing them lets researchers examine complementary neuropeptide scaffolds under identical in-vitro conditions. The bundle is a purchasing convenience for parallel research designs and carries no implication of combined use outside the laboratory.