BPC-157

Description

Overview

BPC-157 is a synthetic pentadecapeptide comprising 15 L-amino acids (sequence H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH). It corresponds to a partial sequence originally identified within a gastric protein and is frequently referenced in the literature as a “body protection compound.” G Peptide Labs supplies BPC-157 strictly as a research reference material intended for in-vitro and preclinical laboratory investigation only. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use.

This lyophilized peptide is manufactured to a documented purity of ≥98% by reversed-phase HPLC, with identity confirmed by mass spectrometry. Each lot ships with a batch-specific third-party Certificate of Analysis (COA) so that researchers can verify what they are working with before an experiment begins.

Research Context

BPC-157 has been the subject of a substantial body of preclinical literature, predominantly in cell-culture systems and animal models. Published work most commonly examines its behaviour in the context of connective-tissue biology, gastrointestinal-tract models, and vascular processes. The interest for laboratory researchers centres on how a small, stable peptide interacts with pathways relevant to tissue repair.

• In cultured tendon explants and isolated fibroblasts, investigators have studied outgrowth, cell survival under oxidative stress, and cell migration.
• Preclinical reviews have catalogued its reported activity across muscle, tendon, ligament, and bone injury models in animals.
• Comparative studies have positioned the peptide alongside standard angiogenic growth factors when examining vascular and gastrointestinal healing in experimental systems.

All such findings are laboratory observations reported by third-party researchers. They are described here to provide scientific context for handling and experimental design, and they do not constitute claims of any benefit in humans.

Mechanism of Interest

Mechanistic reports in the preclinical literature describe several pathways that researchers investigate when working with BPC-157 in vitro and in animal models:

• Angiogenesis-associated signalling — experimental interest in vascular endothelial growth factor (VEGF) pathways and endothelial responses.
• Growth-factor receptor expression — reported up-regulation of the growth hormone receptor in cultured tendon fibroblasts.
• Nitric-oxide system modulation — a frequently cited axis in gastrointestinal and vascular animal models.
• Collagen and fibroblast dynamics — cell-migration and cell-survival endpoints in connective-tissue cultures.

These are areas of active preclinical inquiry rather than established mechanisms, and they are provided solely to orient laboratory study.

Specifications

• Peptide name: BPC-157 (pentadecapeptide)
• Sequence: H-GEPPPGKPADDAGLV-OH (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val)
• Molecular formula: C62H98N16O22
• Molecular weight: ≈1419.5 g/mol (average, free base)
• CAS number: 137525-51-0 (free base)
• Purity: ≥98% by RP-HPLC; identity confirmed by MS
• Physical form: White lyophilized powder
• Counterion: Commonly supplied as the acetate salt; consult the lot COA

Handling, Reconstitution & Storage

BPC-157 should be handled only by qualified personnel using appropriate laboratory practice, personal protective equipment, and fume-management as required by your institutional protocols.

• Storage of lyophilized powder: store sealed at -20 °C, protected from light and moisture; the powder is stable for extended periods under these conditions.
• Reconstitution: researchers typically reconstitute with sterile bacteriostatic or sterile water for laboratory use, adding solvent slowly against the vial wall and swirling gently rather than shaking.
• After reconstitution: aliquot to minimise freeze-thaw cycles; store working solutions refrigerated at 2–8 °C for short-term use or frozen at -20 °C for longer intervals.
• Best practice: allow the vial to reach room temperature before opening to reduce condensation, and record reconstitution date and concentration on each aliquot.

Quality & Verification

Every lot of BPC-157 from G Peptide Labs is accompanied by a batch-specific third-party Certificate of Analysis. The COA documents the analytical evidence behind the material so that results can be attributed to a known, characterised reference compound.

• HPLC chromatogram establishing chromatographic purity (≥98%).
• Mass-spectrometry data confirming the expected molecular weight and identity.
• Lot number and analysis date for full traceability.

We recommend matching the lot number on your vial to the accompanying COA before beginning any experiment. This product is sold in Canada for laboratory research use only.

Selected Research

Peer-reviewed references provided for scientific context; they describe laboratory and preclinical findings only.

1. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH, 2011. PMID: 21030672
2. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules Chang CH, Tsai WC, Hsu YH, Pang JH, 2014. PMID: 25415472
3. BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing. Current Pharmaceutical Design Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, et al., 2018. PMID: 29998800
4. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research Gwyer D, Wragg NM, Wilson SL, 2019. PMID: 30915550