Tirzepatide

Name: Tirzepatide
Brand: G Peptide Labs
SKU: GIP-TIRZ
Availability: InStock

Price range: $125.00 through $199.00

Tirzepatide is a dual GIP/GLP-1 receptor agonist for metabolic research. Available in 30mg, 40mg, and 60mg lyophilised vials at ≥99.8% HPLC purity, independently verified by Janoshik on every batch. For laboratory research use only.

Not for human consumption. Supplied strictly for in-vitro laboratory research use.

Volume pricingper selected size

Quantity	Per vial	You save	Total
1 vial	$125.00	—	$125.00
5 vials −20%	$100.00	$25.00 ea	$500.00
10 vials −40%	$75.00	$50.00 ea	$750.00

Per-vial price drops automatically when you add 5 or 10 of the same vial to your cart.

View Lab Report

Purity (HPLC)99.87%

FormatLyophilised powder

CAS / CodeGIP-TIRZ

Lot2026061030

StorageStore at -20C, protect from light

SKU: GIP-TIRZ Category: Metabolic

Description

Overview

Tirzepatide is a 39-residue synthetic peptide engineered as a single-molecule dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. Its backbone is derived from the native GIP scaffold and is stabilized by two non-coded 2-aminoisobutyric acid (Aib) residues at positions 2 and 13, together with a C20 fatty-diacid moiety attached at Lys20 through a gamma-glutamate linker. This lipidation supports albumin association and extended in-vitro stability, which is a frequent point of interest in laboratory pharmacology models. G Peptide Labs supplies Tirzepatide strictly as a reference material for in-vitro and preclinical scientific investigation. It is not a drug, supplement, or food and is not intended for human or veterinary use.

Research Context

The dual incretin-receptor pharmacology of Tirzepatide has made it a widely studied tool compound in metabolic and receptor-signalling research. In published preclinical work, investigators have used the peptide to probe how simultaneous engagement of GIP and GLP-1 receptors differs from single-receptor agonism at the level of cell-signalling assays and animal disease models. Reported laboratory applications include the characterization of receptor binding and biased signalling in transfected cell systems, and the study of metabolic and neurological endpoints in rodent models. All such work is conducted under controlled laboratory conditions by qualified researchers.

Mechanism of Interest

Dual receptor engagement: Researchers investigate how a single sequence can activate two distinct class-B G-protein-coupled receptors and how the resulting downstream cAMP and beta-arrestin responses are integrated in vitro.
Biased and imbalanced signalling: Preclinical studies have described the molecule as an imbalanced and biased agonist, showing greater relative activity at the GIP receptor than at the GLP-1 receptor in cell-based assays.
Structural modifications: The Aib substitutions and C20 diacid conjugation are studied for their contribution to conformational stability and prolonged in-vitro half-life relative to native incretin peptides.

Specifications

Molecular formula: C225H348N48O68
Molecular weight: 4813.45 g/mol (average)
CAS number: 2023788-19-2
Sequence length: 39 amino acids, C-terminal amide, with non-coded Aib at positions 2 and 13
Purity: greater than or equal to 99% by HPLC (lot-specific; confirmed on the certificate of analysis)
Physical form: lyophilized white to off-white powder
Identity confirmation: mass spectrometry and reverse-phase HPLC

Handling, Reconstitution and Storage

Store the sealed lyophilized vial at -20°C, protected from light and moisture. Brief excursions to room temperature during shipping do not materially affect the lyophilized powder.
For laboratory reconstitution, bacteriostatic or sterile water is commonly used; the peptide is typically dissolved gently without vortexing to limit shear and foaming.
After reconstitution, aliquot to minimize freeze-thaw cycles and store at -20°C or lower for extended periods, or at 2-8°C for short-term working use.
Allow vials to reach room temperature before opening to reduce condensation on the powder.
All handling should follow standard laboratory safety practices, including gloves and eye protection, within an appropriate research setting.

Quality and Verification

Every lot of Tirzepatide from G Peptide Labs is accompanied by a third-party certificate of analysis (COA) documenting HPLC purity, mass-spectrometric identity confirmation, and net peptide content for the specific lot supplied. Researchers are encouraged to match the lot number printed on the vial to the COA and to review the reported purity value, retention profile, and observed mass before use. This documentation supports experimental reproducibility and allows the material to be traced to its analytical record.

Compliance

Tirzepatide is offered for research use only (RUO). It is supplied for in-vitro study and laboratory or preclinical research and must not be used in humans or animals for any therapeutic, diagnostic, or dietary purpose. By purchasing, the buyer confirms they are a qualified professional and will handle the material in accordance with applicable Canadian and local regulations.

Selected Research

Peer-reviewed references provided for scientific context; they describe laboratory and preclinical findings only.

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight Willard FS, Douros JD, Gabe MB, et al., 2020. PMID: 32730231
Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regarding glycaemic control and body weight reduction. Cardiovascular Diabetology Nauck MA, D’Alessio DA, 2022. PMID: 36050763
GLP-1/GIP dual agonist tirzepatide alleviates mice model of Parkinson’s disease by promoting mitochondrial homeostasis. International Immunopharmacology Tian R, Liu K, Lai H, Liao C, Li J, Tu H, 2025. PMID: 40886502
Unveiling Tirzepatide’s Therapeutic Spectrum: A Dual GIP/GLP-1 Agonist Targeting Metabolic, Neurological, and Cardiovascular Health. International Journal of Endocrinology Ghaleb J, Khouzami KK, Nassif N, et al., 2025. PMID: 41069980

Additional information

Size	30mg, 40mg, 60mg

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Frequently asked questions

How is Tirzepatide reconstituted and stored in the laboratory?

The lyophilized powder is typically dissolved in bacteriostatic or sterile water by gentle swirling rather than vigorous mixing, which limits shear and foaming. Store the sealed vial at -20°C away from light and moisture. Once reconstituted, aliquot to avoid repeated freeze-thaw cycles; working solutions are commonly held at 2-8°C short term or frozen at -20°C or below for longer storage. This guidance is for in-vitro research handling only.

What purity can I expect, and how do I verify it?

Each lot is manufactured to greater than or equal to 99% purity by HPLC. Verification is straightforward: match the lot number on your vial to the accompanying third-party certificate of analysis, then review the reported HPLC purity, the chromatographic retention profile, and the mass-spectrometry result confirming the expected molecular weight of 4813.45 g/mol.

What does the certificate of analysis actually confirm?

The COA documents the lot-specific analytical data: HPLC purity percentage, identity confirmation by mass spectrometry, and net peptide content. It links the physical vial to its testing record, which supports reproducibility and traceability in a research setting. It does not certify the material for any human or veterinary application.

Which vial size should I choose for my research?

Size selection depends on your assay scale and how many experiments you plan to run. Smaller quantities suit pilot or single-model studies and reduce material held in storage, while larger quantities suit multi-arm or repeated in-vitro work where consistent lot-to-lot material is preferred. Because Tirzepatide is stable as a lyophilized powder at -20°C, purchasing to your planned experimental volume helps limit freeze-thaw exposure of reconstituted stock.

Do you ship Tirzepatide within Canada?

Yes. G Peptide Labs ships across Canada with packaging suitable for peptide reference materials. The lyophilized powder tolerates brief transit temperature excursions without loss of integrity; on arrival it should be returned to -20°C storage. Orders are supplied for research use only to qualified purchasers.

What is the chemical identity of Tirzepatide?

It is a 39-amino-acid synthetic peptide with molecular formula C225H348N48O68, an average molecular weight of 4813.45 g/mol, and CAS number 2023788-19-2. It carries non-coded aminoisobutyric acid residues at positions 2 and 13 and a C20 fatty-diacid moiety conjugated at Lys20 through a gamma-glutamate linker, features studied for their effect on in-vitro stability.